Advantages of Transdermal Drug Delivery
- Reduce GI side effects: Drug reaches the systemic circulation whilst avoiding first-pass hepatic metabolism.
- Provides smooth plasma concentrations of a drug with less fluctuations, for a long period.
- Drug administration through skin avoids the pH variations seen with gastrointestinal transit.
- Drug intake can be stopped at any point by simply removing the transdermal patch.
- Transdermal patches are noninvasive, avoiding the inconvenience of parenteral therapy.
- The simplified medication regimen leads to improved patient compliance and reduced side effects as well as inter and intra-patient variability.
- Can be route of drug administration of choice in patients who are nauseated or unconscious.
- Equivalent therapeutic effect can be elicited with less amount of dose if given as a transdermal patch as compared to dose of same drug if given orally.
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